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The film depicts the fictional life of Bodhidharma (Suriya), a master of martial arts and medical remedies, who is depicted in the film as the son of a great Tamil king of the Pallava Dynasty.
The film switches to modern-day China, where Dong Lee (Johnny Tri Nguyen) is given the task of starting a government planned biological war against India, known as Operation Red. The disease thus developed was the one which occurred during the time of Bodhidharma in China.
Meanwhile Subha Srinivasan (Shruti Haasan), a student of genetics researches that Bodhidharma can be brought back to life if his sample of DNA is matched with another sample of DNA and thus the disease can be curbed.
Is she able to bring him back? Do they win the war against Dong Lee?