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Anaganaga O Dheerudu is a fantasy adventure film set in the fictitious teardrop shaped land of Sangarashtra. The film tells of the journey of a nine year old girl with special healing powers and her quest to save Sangarashtra from the tyranny of an evil Queen. The girl is protected by a blind swordsman played by Siddharth who faces great adversity and helps the girl on her epic journey. Shruti Haasan plays a gypsy woman whose destiny is tied into that of the swordsman and she plays his love interest.