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Karmayodha focuses on human trafficking of young girls. Madhava Menon(Mohanlal) known as Maddy & Mad Menon by his colleagues initiates the investigation of abduction of girls trapped by the mafia. The film attempts to make society aware of how kids are trapped by the mafia groups who succeed by using technology like mobile phones. The movie also dwells into how flesh trade booming abroad. Apart from depicting child trafficking, Karmayodha is also a family drama and throws light on the diminishing joint family structure in society.