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Mathai (Jayasurya), a native of Thrissur, is an auto driver. He is very innocent and is always ready to help others in their needs. He interferes in the matters of others necessarily and unnecessarily with the intention to help them. But contrary to his expectations, usually he and others get into trouble.
The life of Dr Nandakumar (Mukesh) and his wife Geeta (Lakshmi Gopalaswamy) turns topsy-turvy with Mathai`s influence. The resulting events are plotted hilariously in `Mathai Kuzhappakaranalla`.