'Santha' is the story of Santhosha, an innocent and hard working youngster whose aim is to earn money to secure a good medical treatment for his mentally challenged sisters. And he also loves the girl next door which creates lots of problems for him. He is foisted with a false case and is booked by a crook in the garb of a policeman. Then he is troubled by another don. Santha is forced to take up arms and attack the don. He then serves a Jail sentence where he takes an inevitable step to lead a rival underworld group. Meanwhile, a medical student loves him for his bravery and innocence. The Police commissioner advises Medical student to prevail upon Santha to surrender to the police. Finally, the film ends up in a tragic note with the love element coming into the focus in the climax.