Santha` is the story of Santhosha, an innocent and hard working youngster, who aims to earn money enough to provide good medical treatment to his mentally challenged sisters. However, he is framed in a case by a brute, making him go to prison. Here, he leads an underworld group to revival, and embarks upon the path of crime and violence. Meanwhile, a medical student falls in love with his bravery and innocence. The Police commissioner advises Medical student to prevail upon Santha to surrender to the police. Will she be able to have Santha surrender, or will things take a bitter turn towards the end?