In an interview The Falcon and the Winter Soldier (via SFX) showrunner Malcolm Spellman indicated that the series will address a real world event in a subtle way. Spellman says that the show will cover the effects of the MCU’s blip on the world at large, but he also says that this will tie in to the coronavirus pandemic in interesting and subtle ways. He says that the disappearance of four billion people in the MCU can be viewed as a sort of parallel to what has happened in the last year with the pandemic and that The Falcon and the Winter Soldier‘s tackling of the repercussions of the blip will mirror the real world.
There’s no hiding from the fact that four billion people in the MCU disappeared for five years, and then came back. And our show picks up from there and directly talks about what the world feels like to be in flux and dealing with one global issue.
From the quote it seems like the show is definitely going for a more grounded in it’s subject matter than WandaVision‘s meta and existential approach.