Hailing from a family of musicians, S. Mahathi is a child prodigy. Her father Sri. Thiruvaiyar P. Sekar, a Vocalist is a disciple of Padmavibhushan Dr. M. Balamurali Krishna. Her mother Smt. Vasanthi Sekar is a Flutist, is the grand disciple of Sri. T. R. Mahalingam, Sri. N. Ramani and Smt. Kesi. She is the great-granddaughter of the famous violinist “Sangeetha Kalanidhi” Pazhamaneri Swaminatha Iyer. Mahathi is 'Direct B High graded artiste of the All India Radio and a renowned play-back Singer. She has been awarded the scholarship for Classical Music from the central Government of India in the year 1994 at Trichur (Kerala). She began tosing in various Devotional albums and sang for some Malayalam movies. She introduced herself in a Tamil film, music composed by the great Isai Gnani Illayaraja with a solo song “Enna Maranthalum” in the movie “Kaadhal Jaathi”. Her smash hit “Aiyyaiyyo Pudichirukku”, a duet song with Sri. Hariharan, composed by Sri. Harris Jeyaraj in Vikram’s “Saamy” made her popular among Tamil music lovers. She bagged many awards and accolades from reputed music organizations.