The Amazing Spider-Man is the story of Peter Parker (Garfield), an outcast high schooler who was abandoned by his parents as a boy. He was raised by his Uncle Ben (Sheen) and Aunt May (Field).
Now Peter is trying to figure out who he is and how he got to be the person he is today. When Peter discovers a mysterious briefcase that belonged to his father, he begins to question their disappearance.
The clues lead him to Oscorp and the lab of Dr. Curt Connors (Ifans), his father's former partner.