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Gru is no longer a villain since he rescued his 3 foster daughters, Margo (Miranda Cosgrove), Edith (Dana Gaier), and Agnes (Elsie Fisher) from Vector in `Despicable Me`. But his calm and unexciting new life takes an unexpected turn when he is recruited by Lucy Wilde and Silas Ramsbottom and is taken to the headquarters of the Anti-Villain League, a society dedicated to fighting crime on a global scale. There, he discovers that Eduardo, a new villain is on the loose. Since Gru was once a villain himself and knows how they think, Silas (who is the League`s head) wants Gru to help them fight Eduardo. Can Gru fight Eduardo and save the world?