A salesman during the day and a theater actor during the night - Pratik Gandhi juggled between his passion and profession until he finally found success with the Gujarati play Aa Paar Ke Pele Paar. The play went on to become a commercial success and soon Pratik featured in several plays such as Apurva Avsar, Hun Chandrkant Bakshi, Master Madam, and Mere Piya Gaye Rangoon.

In 2006, Pratik made his feature debut with the United Kingdom-Indian co-produced film Yours Emotionally. It was in 2014 that he made his Gujarati film debut with the movie Bey Yaar directed by Abhishek Jain. He has since then appeared in movies such as Wrong Side Raju (2016), Tamburo (2017), and Love Ni Bhavai (2017). In 2018, he appeared alongside Jackie Shroff and Ojas Rawal in Umang Vyas`s Gujarati drama Ventilator. His other releases include Dhunki, Luv Ni Love Storys and Ravan Leela