Best known for playing mostly supporting roles in the Hindi film and TV industry, Yatin Kareykar is a veteran actor who started his career with Katha (1983). He subsequently featured in several popular Hindi films including Holi (1985), Qayamat Se Qayamat Tak (1988), Hey Ram (2000), Munnabhai M.B.B.S. (2003), Iqbal (2005), The Hangman (2005), Kalyug (2005), Soundtrack (2011), Bajirao Mastani (2015), Wedding Anniversary (2017) and Downup the Exit 796 (2018). Apart from films, Yatin also made his debut on the small screen with the hit TV series, Byomkesh Bakshi (1993). But it was the popular drama Shanti (1994) that eventually made Yatin a household name. While he played Kamesh Mahadevan, Mandira Bedi played the titular character, Shanti. He also portrayed Aurangzeb in the hit Marathi historical TV drama, Raja Shivchhatrapati (2008-2009). Yatin`s other popular television appearances include Sarabhai vs Sarabhai (2004), Crime Patrol (2010), and Saraswatichandra (2013). Yatin has also acted in Marathi movies like Sarkarnama (1998), Aaila Re!! (2006), Gandha (2009), Tukaram (2012), Vitti Dandu (2014), Dagadi Chaawl (2015), Anaan (2017), and Tula Pan Bashing Bhandhaychay (2018).

In 2018 Yatin starred in Rahul Bhole and Vinit Kanojia`s Gujarati drama, Reva. The cast also includes Abhinay Banker, Monal Gajjar, Prashant Barot, Rupa Borgaonkar, and Dayashankar Pandey in important roles. The movie is based on the 1998 novel "Tatvamasi" by renowned Gujarati writer Dhruv Bhatt. His 2019 projects include PM Narendra Modi, Ek Hota Pani, A1, Bakaal and The Warrior Queen of Jhansi. His 2020 release includes Bhaybheet.