Karthik Anitha as the name implies is a story about two college going youngsters played by new faces Rathan and Manju respectively. Karthik lives with his dad ( Kota Srinivasa Rao) who dotes on him since his mother is long dead. Anitha is his neighbour who lives with her parents and little sister in the opposite house in a middle class colony. Both are childhood friends and even study at the same college. However they are constantly at loggerheads and playing tricks to get even with each other. One day however, a prank gets out of hand and Karthik starts hating Anitha who in turn discovers that she loves him. The problem is accentuated when her wedding is fixed to another guy. This is when Karthik realizes his love for Anitha. But is it too late for his confess, or will Anitha still accept his feelings in reciprocation to her own?
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