Based on a true story, Masterminds follows the riotous misadventures of unlikely anti-hero David Ghantt (Zach Galifianakis) as he pulls off one of the largest robberies in U.S. history. The trouble begins when David, a trusted armored-truck driver for Loomis Fargo, falls for beautiful guard Kelly Campbell (Kristen Wiig). After she quits her job, Kelly, egged on by local petty thief Steve Chambers (Owen Wilson), persuades David to clean out the companys vault in Charlotte, North Carolina.
After stuffing a van with more than $17 million of stolen cash, David delivers the money to Chambers gang and flees to Mexico to lie low while the FBI searches for the culprits. Steve and his wife Michelle (Mary Elizabeth Ellis) buy a mansion with their ill-gotten wealth and dispatch overzealous hit man Mike McKinney (Jason Sudeikis) to Mexico to kill David. Once David discovers the betrayal, he returns to North Carolina on a mission to rescue his true love and expose Steve as the heists real mastermind.
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