Anjena Kirti started her career as a cabin crew in Etihad Airways, but following her passion for model and acting, she quit her job and pursued an acting career in Tamil film industry. Kirti made her silver screen debut in Azhagiya Pandipuram in 2014. She, then, went on to play leading role in 2015 film Thirandhidu Seese alongside Sai Dhanshika. Her significant roles are Andhadhi (2015) and Jambulimgam 3D (2016). She also starred in Venkat Prabhu`s Chennai 600028 II, where she was seen as a North Indian girl opposite Vijay Vasanth. Her other ventures include R. K. Nagar (2018). Her 2021 release includes Maanaadu.