A well-known face in Kannada film industry, film actress Girija Lokesh started her acting career with the film Abachurina Post Office in the year 1973. She later went on to star in numerous films, including Abachurina Post Office (1973), Kakana Kote (1977), Simhasana (1983), Challenge Gopalakrishna (1990), Anukoolakkobba GandaRamachaari (1991), Mana Mecchida Sose (1992), Gadibidi Ganda (1993), Yarigu Helbedi (1994), Ulta Palta (1997), Ganga Yamuna (1997), Nanda Loves Nanditha (2008), Aithalakkadi (2010), Sidlingu (2012), Manjunatha BA LLB (2012), Bhajarangi (2013), Gajakesari (2014), Bullet Basya (2015), Krishna-Rukku (2016), Kiragoorina Gayyaligalu (2016), and John Jani Janardhan (2016). Her other projects include Style Raja (2017), Kaanoorayana (2018), Bhootayyana Mommaga Ayyu (2018), Surya Eva Vrukshamitra (2018) and Hassiru Ribbon (2018).
In addition, Girija Lokesh has also produced 1983 film Karune Illada Kanoonu, being the only film she produced in her entire career. His 2019 releases include Seetharama Kalyana and Nanna Prakara.