Primarily known for appearing in character roles in Hindi cinema, Jeetendra Shastri has a handful of critically acclaimed films to his credit. Among these are the biographical drama Bandit Queen (1994), the epic historical drama Asoka (2001) and the docudrama Black Friday (2007).

Significant acting credits in recent times include the social drama Sui Dhaaga: Made in India (2018) and the comedy-drama Rajma Chawal (2018). His 2019 release includes Sonchiriya.