An MBA graduate by qualification and an actor by profession, Madhu Nandan is one of the most sought-after comedians in contemporary Telugu cinema. He made his feature film debut in the 2001 romantic drama Nuvvu Nenu, and got his big break courtesy of his performance in the romantic comedy-drama Gunde Jaari Gallanthayyinde (2013). Notable film credits include Sye (2004), Ishq (2012), Rabhasa (2014), and S/o Satyamurthy (2015).

The drama film Brahmotsavam (2016), the horror thriller Bhaagamathie (2018), the romantic drama Chal Mohan Ranga (2018), the Ravi Teja starrer Nela Ticket (2018) and Vinaya Vidheya Rama (2019). His 2020 release includes Hulchul.