Mona Ambegaonkar`s showbiz career spans around three decades, in the course of which she has appeared in over 20 films, numerous tv shows and several plays in both Marathi and Hindi. The actress, whose early works include films like Zakhmi Zameen (1990) and Baharon Ke Manzil (1991), is perhaps best known for her supporting roles in the Bollywood historical biographical drama Mangal Pandey (2005) and the crime thriller Mardaani (2014). Besides these, she has also had a recurring role in the long-running crime anthology series C.I.D.

The Sony TV show, Dhadkan, Sanjivani and Kaala Teeka are some of Mona`s other notable acting credits on television. Significant film credits also include Bindhaast (1999), Phir Bhi Dil Hai Hindustani (2000), Gandhi, My Father (2007), Pyaar Ka Punchnama 2 (2015), the 2017 musical drama Secret Superstar and the 2018 romantic drama Kuchh Bheege Alfaaz.

Mona Ambegaonkar continued her career as an Actor in 2019 with the drama Evening Shadows (2019). In 2022, she appeared as an Actor in the romantic drama Tara vs Bilal (2022). Her 2023 work included the musical drama Music School (2023). In 2025, she featured as an Actor in Kuch Sapney Apne (2025), and her work in 2026 includes her role as an Actor in the romantic drama Do Deewane Seher Mein (2026).