A renowned casting director, Mukesh Chhabra primarily works in the Hindi film industry. His casting in the National Award-winning film Chillar Party gained him nationwide recognition, post which Anurag Kashyap roped him in for the cult hit Gangs of Waaseypur. Further, he is associated with films like Kai Po Che (2013), Highway (2014), Haider (2014), Tamasha (2015) and Dangal (2016).

His other notable projects include Raman Raghav 2.0 (2016), Tubelight (2017), Shubh Mangal Saavdhan (2017), Bhavesh Joshi Superhero (2018), Soorma (2018), Dhadak (2018), Laila Majnu (2018), Rajma Chawal (2018), Mard Ko Dard Nahi Hota (2019), Super 30 (2019), Chhichhore (2019), Laal Kaptaan (2019), Made In China (2019), Housefull 4 (2019) and Panga. In 2020, he made his directorial debut with the romantic-drama movie Dil Bechara. His 2021 project includes the musical romantic movie 99 Songs, directed by Vishwesh Krishnamoorthy.