Nandana Varma made her debut as a child artist in the 2016 Malayalam drama film Guppy, which went on to win several top honours at the Kerala State Film Awards that year. She has since gone on to establish herself as an up-and-coming young artist through her performances in films like Paulettante Veedu (2016) and Sunday Holiday (2017). Other notable acting credits include the comedy-drama Aakasha Mittayi (2017), the family drama Mazhayathu (2018), Mohabathin Kunjabdulla (2019) and Rajavukku Check (2020).