Prabhas Sreenu is a popular male comedian who is known for his work in Telugu cinema. He featured in the action drama Uu Kodathara Ulikki Padathara in 2012, under the direction of Sekhar Raja, and then went on to be a part of several movies like Seethamma Vakitlo Sirimalle Chettu, Express Raja, and Savitri. He also starred in the action thriller Thikka (2016), under the direction of Sunil Reddy, starring Sai Dharam Tej and Larissa Bonesi in the lead roles.

Sreenu played a supporting role in the movie, which received only mixed to negative reviews from critics. He was part of the Rana Daggubati starrer Nene Raju Nene Mantri (2017), a political thriller which was a huge box office success and also received positive reviews. He was also seen in the action comedy Raja the Great (2017), directed by Anil Ravipudi, starring Ravi Teja and Mehreen Pirzada in the lead roles, which also was a huge success.

His 2018 ventures include G. Ashok`s directorial Bhaagamathie, a horror-thriller starring Anushka Shetty and Krishna Chaitanya`s directorial Chal Mohan Ranga starring Nithiin and Megha Akash in lead role. His 2019 releases include Prasnistha, BurraKatha and Raju Gari Gadhi 3.