A former MBA graduate and model, Ranadheer Gatla made his acting debut in the acclaimed coming of age musical drama Happy Days (2007), and has since appeared in supporting roles in several Telugu films. Some of Ranadheer's best known acting credits include Yuvatha (2008), the comedy-drama Pilla Zamindar (2011) and the romantic comedy action film Subramanyam for Sale (2018).

The Ram Charan starrer Dhruva (2016) and the horror thriller Lalijo Lalijo (2018) are among Ranadheer's notable film credits in recent times.