Samyuktha Menon first ventured into the world of cinema in 2016, with the Mollywood comedy Popcorn. Though the film failed to make a major impact at the box office, Samyuktha`s confident performance despite being a debutante was well-received. Notable among the actress` most recent works is the comedy film Theevandi (2018), where she starred alongside Tovino Thomas, Lilli (2018) and Ezhumin (2018). Her 2019 releases include July Kaatril, Sundaram, Oru Yamandan Prema Kadha, Uyare, Kalki, Edakkad Battalion 06 and Under World. Her other notable works include Vellam: The Essential Drink (2021), Aanum Pennum (2021), Wolf (2021), Erida (2021), Bheemla Nayak (2022), Kaduva (2022), Bimbisara (2022), Gaalipata 2 (2022). Her other releases include Boomerang (2023), Vaathi (2023), Sir (2023) and Virupaksha (2023).