Siddique is a Malayalam film actor who made his debut in the film Aa Neram Alppa Dooram (1985). Following this, Siddique was cast in films like New Delhi (1987), Boomiyile Rajakkanmar (1987), Pradeshika Vaarthakal (1989) and Kaalal Pada (1989). His breakthrough performance was in the film In Harihar Nagar (1990), after which, he went on to star in films like Mookkilyarajyathu (1991), Mimics parade (1991), Thiruthalvadhi (1992), Ekalavyan (1993) and Chinthavishtayaya Shyamala (1998). Some of his most popular films include Megamalhar (2001),Kalyanaraman (2002), In Harihar Nagar (2009), Pranchiyettan, The Saint (2010), Grandmaster (2012), Celluloid (2013), Vellimoonga (2014), Pathemari (2015) and Puthan Panam (2017). His 2018 releases include Aadhi, Hey Jude, Captain, Kammara Sambhavam and Parole. He is associated with the 2018 action-comedy-drama Angane Njanum Premichu directed by Rajeev Varghese.