Most prominent for his role in the 1994 film Ishq, Tiku Talsania has come a long way with significant roles in several films like Andaz Apna Apna, Raja Hindustani, Hungama, Dhol and Special 26. He has also featured in various television serials like Golmaal Hai Bhai Sab Golmaal Hai, Uttaran, and Sajan Re Jhoot Mat Bolo, to name a few. He is also a freelance theatre artist for Gujarati theatre in Mumbai, America and Europe. His 2017 venture includes the comedy film Aav Taru Kari Nakhu, under the direction of Rrahul Mevawala and the Bollywood comedy, Patel Ki Punjabi Shaadi, directed by Sanjay Chhel. His 2019 release includes Life Mein Time Nahi Hai Kisi Ko.