A South Indian actor, Antony Varghese marked his silver screen debut in a comedy-drama Malayalam movie Angamaly Diaries (2017), opposite Amritha Anna in the lead role. He has been a part of the films such as 2018 release Swathanthriyam ArdhaRathriyil. His other releases include Jallikattu (2019) and Ajagajantharam (2021).

Starting from 2022, he appeared as an Actor in the streaming thrillers Innale Vare (2022) and Super Sharanya (2022, cameo), as well as the sports drama Aanaparambile World Cup (2022) and romantic comedy Oh Meri Laila (2022). In 2023, he starred in Poovan (2023), the blockbuster action-drama RDX (2023), and the action-thriller Chaaver (2023).

His recent work includes the maritime action film Kondal (2024), followed by the sports drama Daveed (2025), the action-thriller Kattalan (2026), and the action-thriller I'm Game (2026).