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Ami Thumi is a screwball comedy about two couples, played by Adivi Sesh and Eesha Rebba and Srinivas Avasarala and Aditi Myankal respectively, and their unexpected encounter with an eccentric man played by Vennela Kishore, who turns their lives upside down with hilarious consequences.
The rest of the plot consists of the various events that unfold, with riotously hilarious consequences, leading to a zany and hysterical climax.