Siddique is a Malayalam film actor who made his debut in the film Aa Neram Alppa Dooram (1985). Following this, Siddique was cast in films like New Delhi (1987), Boomiyile Rajakkanmar (1987), Pradeshika Vaarthakal (1989) and Kaalal Pada (1989). His breakthrough performance was in the film In Harihar Nagar (1990), after which, he went on to star in films like Mookkilyarajyathu (1991), Mimics parade (1991), Thiruthalvadhi (1992), Ekalavyan (1993) and Chinthavishtayaya Shyamala (1998).

Some of his most popular films include Megamalhar (2001), Kalyanaraman (2002), In Harihar Nagar (2009), Pranchiyettan, The Saint (2010), Grandmaster (2012), Celluloid (2013), Vellimoonga (2014), Pathemari (2015) and Puthan Panam (2017). His 2018 releases include Aadhi, Hey Jude, Captain, Kammara Sambhavam, Parole, Angane Njanum Premichu, Oru Kuprasidha Payyan, Iblis, Drama, and Oru Kuttanadan Blog, Aanakallan and Odiyan. His 2019 projects include Madhuraraja, Uyare, Isakkinte Ithihasam, Ittymaani: Made in China, Ganagandharvan, Happy Sardar, Ulta and My Santa. His 2020 releases include Uriyadi, Shylock and Sufiyum Sujathayum. His 2021 releases include Drishyam 2 and Mohan Kumar Fans.